ABSTRACT
Curcuma longa, commonly called Turmeric, is a plant, belonging to family Zingiberaceae (ginger family) which has been used in traditional medicine for the management of several diseases such as diabetic ulcers, rheumatic conditions, external wounds and cough. Diferuloylmethane is the most active chemical extract found in Curcumin, has been shown to exert antioxidant, antiaging, anti-inflammatory, immunomodulatory, wound healing, antitumoral and antipsoriatic effects. Delayed wound healing is a very common complication associated with diabetic patients, following extractions. Recent research has suggested that curcumin has great potential to address this.METHODSA total of 11 patients, who satisfied the inclusion criteria (RBS= <200 mg/dL) were selected from the out-patient department of Oral and Maxillofacial Surgery, FDS- RUAS. They were then divided into two groups – test and control, comprising of 6 in test group 5 in control group. Following the extraction, in the test group patients, Curcuma oral gel was placed, within the extraction socket. Both the groups were given standard post-extraction instructions. Healing of both study and control group extraction sockets were assessed on day 0, day 3 and day 7 respectively.RESULTSThe study group patients showed statistically significant reduction in the width of extraction socket on day 3 [mesial (p-value =0.03)] and day 7 [mesial (p-value =0.002)]. Central (p-value =0.03) and Distal (p-value =0.03)) and significant reduction of pain by day 7 (0.002).CONCLUSIONSCurcumin is a safe, natural herb, giving good results in the healing of the extraction socket in diabetic patients, with definite improvement in the soft tissue healing.
ABSTRACT
Nasal polyps are one of the most common inflammatory mass lesions of the nose. Their etiology remainsunclear, but they are known to have associations with allergy, asthma, infection, fungus,cystic fibrosis, andaspirin sensitivity. However, the underlying mechanisms interlinking these pathologic conditions to nasal polypformation remain unclear. In the present cross-sectional study was carried with 100 patients diagnosed withnasal polyposis in the age group of 10-60 years of both the sexes were studied during this period from June 2014to October 2015 in the department of ENT, Kakatiya medical college attached to MGM Hospital, Warangal werefound in large majority age groups of 11 – 30 years, men are most commonly seen affecting than women (men:women are 2:1).Allergic rhinitis is strongly associated with nasal polyposis, most common symptom is nasalobstruction, anosmia and facial pain are also seen.Most of the patients had nasal polyps reaching beyond themiddle turbinate. And also, most of the patients had bilateral ethmoidalopacification on CT scan.only fewshowed sphenoid and frontal opacities.Steroid therapy was useful in 38% of patients.All others required endoscopic sinus surgery. Also, strong genetic factors are implicated in the pathogenesis of nasal polyps, but geneticand molecular alterations required for its development and progression are still unclear